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TABLE 2-14:

Fold Change Cutoffs for Phenotype and VircoTYPE Assays
Drug Monogram
PhoneSense		 Virco
Antivirogram		 Virco
VircoTYPE
LCO UCO SCO B/C LCO UCO BCO CCO
1		 CCO
2		 BC
O
  NRTI/NtRTI
abacavir ABC 4.5 6.5   C 3.2 7.5 2.2 0.9 3.5  
didanosine ddl 1.3 2.2   C     2.2 0.9 2.6  
emtricitabine FTC     3.5 B     3.5     3.1
lamivudine 3TC     3.5 C     2.4 1.2 4.6  
stavudine d4T     1.9 C     2.3 1.0 2.3  
tenofovir DF TDF 1.4 4.0   C     2.1 1.0 2.3  
zidovudine AZT     1.9 B     2.7 1.5 11.4  
delavirdine DLV     6.2 B            
efavirenz EFV     3.0 B     3.4     3.3
etravirine ETR               1.6 27.6  
nevirapine NVP     4.5 B     5.5     6.0
amprenavir APV             2.2      
amprenavir/ritonavir APV/r                    
atazanavir ATV     2.2 C     2.4      
atazanavir/ritonavir ATV/r     5.2 C       2.5 32.5  
darunavir/ritonavir DRV/r 10.0 90.0   C 10 40.0 2.4 10.0 106.9  
fosamprenavir FPV     2.0 B            
fosamprenavir/ritonavir FPV/r 4.0 11.0   C       1.5 19.5  
indinavir IDV     2.1 B     2.4 1.0 5.4  
indinavir/ritonavir IDV/r     10 C       2.3 27.2  
lopinavir/ritonavir LPV/r 9.0 55.0   C 10 40.0 1.7 6.1 51.2  
nelfinavir NFV     3.6 B     2.2 1.2 9.4  
ritonavir RTV     2.5 B            
saquinavir SQV     1.7 B     1.8      
saquinavir/ritonavir SQV/r 2.3 12.0   C       3.1 22.6  
tipranavir/ritonavir TPV/r 2.0 8.0   C 3.0 10.0 1.8 1.5 7.0  
LCO = lower cutoff
UCO = upper cutoff
SCO = single cutoff		 B = biological
C = clinical		 CCO1 = lower clinical cutoff
CCO2 = upper clinical cutoff
BCO = biological cutoff
2007 © John G. Bartlett, M.D. All rights reserved.43

Chapter 2: Laboratory Tests

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