| Mutation |
Comment |
I54V/M/L/T/
S/A |
I54V: Increases resistance to PIs when combined with other PI
mutations. I54M/L: Selected by APV or FPV, causing low to
intermediate resistance. Contributes to DRV resistance in presence of
other DRV mutations. I54T/S/A: Effect on PI susceptibility unknown.
I54A/M/V: Contribute to TPV resistance in presence of other TPV
mutations. |
| Q58E |
Contributes to TPV resistance in presence of other TPV mutations. |
L63A/C/E/H/P/
Q/R/S/T/V/I |
L63P: Common polymorphism that increases PI resistance when
combined with other PI mutations. Others: Effect on PI susceptibility
unclear. |
| H69K |
Contributes to TPV resistance in presence of other TPV mutations. |
| A71V/T/I |
A71V/T: Decreases susceptibility to all PIs when combined with other
mutations. A71I: Effect on PI susceptibility unknown. |
| G73S/C/T/A |
G73S/C/T: Resistance to NFV, IDV, SQV, ATV in combination with
other PI mutations. G73A: Uncommon variant. |
| T74P |
Contributes to TPV and DRV resistance in presence of other mutations. |
| L76V |
Decreases LPV susceptibility to unknown degree. Contributes to DRV
resistance in presence of other DRV mutations. |
| V77I |
Polymorphism associated with slight decrease in NFV susceptibility. |
V82A/T/F/S/
I/G/L |
V82A/T/F/S: Primary PI mutation that reduces susceptibility to LPV,
IDV, RTV, and also to NFV, SQV, APV, ATV when combined with other
PI mutations. V82I: Polymorphism with minimal effect on PI
susceptibility. V82M: Seen with subtype G infection; reduces IDV
susceptibility. V82L/T: Contribute to TPV resistance in presence of
other TPV mutations. |
| N83D |
Contributes to TPV resistance in presence of other TPV mutations. |
| I84V/A/C |
I84V: Decreases susceptibility to all PIs: greatest effect on APV, NFV,
SQV, lowest on LPV. Contributes to TPV and DRVresistance in
presence of other mutations. I84A/C: Effects similar to I84V, but rare. |
| N88S/D |
N88D: Intermediate resistance to NFV; low-level resistance to SQV,
ATV. N88S: Intermediate resistance to NFV, ATV; low-level resistance
to IDV; hypersusceptibility to APV. |
| L89V: |
Contributes to DRV resistance in presence of other DRV mutations. |
| L90M |
By itself, causes intermediate resistance to SQV and NFV and low-level
resistance to other PIs. Contributes to TPV resistance in presence of
other TPV mutations.except TPV. |
| I93L/M |
I93L: Common polymorphism that increases PI resistance when
combined with other PI mutations. I93M: PI mutation with unknown
effect on PI susceptibility. |
TABLE 2-13: